HTX-001 is a first-in-class antisense oligonucleotide designed to downregulate WISPER lncRNA, a driver of fibrosis in the heartPhase 1a/b trial to evaluate the safety and tolerability of HTX-001 in ...

Cancer immunotherapy has advanced the field of medicine and cancer care. Specifically, immunotherapy refers to the targeted treatment of the immune system. Over the last few decades, immunotherapy has ...

UH engineers helped develop an mRNA-based strategy that boosts cancer-fighting T cells and, in mouse studies, helped ...

A team led by researchers has discovered that a group of cells located in the skin and other areas of the body, called neural crest stem cells, are the source of reprogrammed neurons found by other ...

Leuven, 11 March 2025 – Solid tumors often provide a challenging environment for the T cells of our immune system. By reprogramming the metabolism of T cells, scientists at the VIB-KU Leuven Center ...

A mature cell of one type can be turned into a mature cell of another type without the cell having to pass through an earlier stage of development. This is called direct reprogramming, a reliable but ...

A new paper in the journal Nature reveals an astonishing—and frankly unsettling—feature of some cancer cells: the ability to physically inject mitochondria into their neighboring cells. These ...

In order to reprogram readily available cells into specific immune cells that fight various diseases, one must know the "recipe" for the transformation. Researchers at Lund University have now created ...

Researchers at Oregon Health & Science University have uncovered a key reason why immunotherapy has largely failed in pancreatic cancer—and identified a promising strategy to overcome that resistance.

Researchers have discovered that SARS-CoV-2, the virus that causes COVID-19, may be changing crucial white blood cells called neutrophils so that instead of working to destroy pathogens, they instead ...