PTIR calculates the rates at which originally monomeric proteins are transformed into aggregates at various temperatures under initial-rate settings. Utilizing SMSLS for identical conditions generates ...

Researchers have identified a backup mechanism of protein quality control which prevents the toxic effects of protein aggregation in specific tissues when normal methods of molecular monitoring fail.

Yeast prions are increasingly recognised as pivotal agents in non-Mendelian inheritance, whereby protein conformations rather than nucleic acids dictate heritable traits. In Saccharomyces cerevisiae ...

Protein aggregation is typical of various neurodegenerative diseases such as Alzheimer's, Parkinson's and prion diseases such as Creutzfeld-Jakob disease. A research team has now used new in vitro and ...

Raghu R. Chivukula, MD, Ph.D., a physician-investigator in the Departments of Medicine & Surgery and the Center for Genomic Medicine at Massachusetts General Hospital and Harvard Medical School, is ...

Researchers have used computational models to understand what drives the accumulation of alpha-synuclein protein, a key culprit in the development of Parkinson’s disease. The study, published today as ...

Micro- and nanoplastics are increasingly detected in human tissues, including the brain, and experimental evidence suggests ...

Researchers headed by a team at the Centre for Genomic Regulation, Barcelona Institute of Science and Technology and at the Wellcome Sanger Institute have developed an AI tool that they say has made a ...

Back when James Parkinson first described the disorder now known as Parkinson’s disease, he noticed that severe constipation can be a prelude to the signature tremors. In the 208 years since then, ...

Neurodegenerative diseases such as Alzheimer's, Parkinson's, Huntington's, and amyotrophic lateral sclerosis (ALS) affect ...

Proteins form the building blocks of life, but when they form unusual clumps inside the brain, they raise an alarm that ...