Researchers at the Icahn School of Medicine at Mount Sinai have characterized how cellular senescence—a biological process in ...

T cell senescence occurs in the TME, affecting cancer prognosis and immunotherapy efficacy. The TME induces T cell senescence through multiple pathways, including persistent stimulation by ...

Explore the connection between neurodegeneration and cellular senescence in understanding brain structure and ageing.

There exists a complex synergistic relationship among cancer, circadian rhythms, and aging: aging is a major risk factor for cancer, disruption of circadian rhythms promotes tumor initiation and ...

After a finite number of divisions, cells simply give up. As each round of replication trims their telomeres—the protective caps at the chromosome ends—those caps eventually become too short to ...

Findings from the Living Brain Project reveal how senescence processes involved in early brain development may also shape brain aging ...

These patients can get as many as five different cancers before the age of 70, indicating that in people with normal length telomeres, the telomere tumor suppressor pathway prevents many cancers." ...

Leaf senescence determines the duration of photosynthesis, nutrient remobilization efficiency, and ultimately crop yield and quality. Cytokinins are well known for delaying senescence by maintaining ...

Population aging is reshaping the landscape of respiratory disease, with COPD, idiopathic pulmonary fibrosis, bronchiectasis, ...